Lab-on-a-Chip (LoC) devices have been used in a plethora of applications, ranging from basic bio-chemistry research, to chemical synthesis, genomics, proteomics, clinical diagnostics and drug discovery. Finally, we demonstrate our SPLoC on four diverse, real-world assays.
We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. In this paper, we develop a multi-purpose, software-programmableLab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment.
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